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Index > Protein center > Nefl(Gene name) > Mouse
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  • Nefl (Gene name),
  • Neurofilament light polypeptide (Protein name ),  NFL_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Nefl(Nf68;Nfl);
    Protein name:
    Neurofilament light polypeptide(NF-L);
    Alternative:
    Neurofilament triplet L protein;68 kDa neurofilament protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with RGNEF. Interacts with TRIM2.
    Function:
    Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    543
    Sequence:
    50:
    MSSFGYDPYF | STSYKRRYVE | TPRVHISSVR | SGYSTARSAY | SSYSAPVSSS | 
    100:
    LSVRRSYSSS | SGSLMPSLEN | LDLSQVAAIS | NDLKSIRTQE | KAQLQDLNDR | 
    150:
    FASFIERVHE | LEQQNKVLEA | ELLVLRQKHS | EPSRFRALYE | QEIRDLRLAA | 
    200:
    EDATNEKQAL | QGEREGLEET | LRNLQARYEE | EVLSREDAEG | RLMEARKGAD | 
    250:
    EAALARAELE | KRIDSLMDEI | AFLKKVHEEE | IAELQAQIQY | AQISVEMDVS | 
    300:
    SKPDLSAALK | DIRAQYEKLA | AKNMQNAEEW | FKSRFTVLTE | SAAKNTDAVR | 
    350:
    AAKDEVSESR | RLLKAKTLEI | EACRGMNEAL | EKQLQELEDK | QNADISAMQD | 
    400:
    TINKLENELR | STKSEMARYL | KEYQDLLNVK | MALDIEIAAY | RKLLEGEETR | 
    450:
    LSFTSVGSIT | SGYSQSSQVF | GRSAYSGLQS | SSYLMSARSF | PAYYTSHVQE | 
    500:
    EQTEVEETIE | ATKAEEAKDE | PPSEGEAEEE | EKEKEEGEEE | EGAEEEEAAK | 
    543:
    DESEDTKEEE | EGGEGEEEDT | KESEEEEKKE | ESAGEEQVAK | KKD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse NF-L
    Cat.:
    E10709h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse NF-L
    MSDS:
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    ELISA Kit for Mouse NF-L
    MSDS:
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    ELISA Kit for Mouse NF-L
    Cat.:
    E10709m
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    96T
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    ELISA Kit for Mouse NF-L
    Cat.:
    E10709r
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    MSDS:
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    96T
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    CLIA Kit for Mouse NF-L
    Cat.:
    U10709m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse NF-L
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse NF-L
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse NF-L
    Cat.:
    U10709h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse NF-L
    Cat.:
    U10709r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse NF-L
    Polyclonal Antibody for Mouse NF-L
    Cat.:
    P10709Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse NF-L
    Polyclonal Antibody for Mouse NF-L
    Polyclonal Antibody for Mouse NF-L
    Monoclonal Antibody for Mouse NF-L
    Monoclonal Antibody for Mouse NF-L
    Monoclonal Antibody for Mouse NF-L
    Monoclonal Antibody for Mouse NF-L
    Monoclonal Antibody for Mouse NF-L
    Protein for Mouse NF-L
    Protein for Mouse NF-L
    Protein for Mouse NF-L
    Protein for Mouse NF-L
    Protein for Mouse NF-L

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and developmental expression of the murine neurofilament gene family."
      Julien J.-P. , Meyer D. , Flavell D. , Hurst J. , Grosveld F.
      Brain Res.387:243-250(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    2. 2.
      "Anomalous placement of introns in a member of the intermediate filament multigene family: an evolutionary conundrum."
      Lewis S.A. , Cowan N.J.
      Mol. Cell. Biol.6:1529-1534(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Brain.
    3. 3.
      Jensen K.H. , Brown A.
      Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Cerebellum.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Eye.
    5. 5.
      "Structure of the 68-kDa neurofilament gene and regulation of its expression."
      Nakahira K. , Ikenaka K. , Wada K. , Tamura T.A. , Furuichi T. , Mikoshiba K.
      J. Biol. Chem.265:19786-19791(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28
    6. 6.
      Lubec G. , Klug S.
      Submitted (2007-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 38-54; 117-126 AND 381-391;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Hippocampus.
    7. 7.
      "Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport."
      Sihag R.K. , Nixon R.A.
      J. Biol. Chem.266:18861-18867(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 52-57;PHOSPHORYLATION AT SER-56
    8. 8.
      "Genetics, evolution, and expression of the 68,000-mol-wt neurofilament protein: isolation of a cloned cDNA probe."
      Lewis S.A. , Cowan N.J.
      J. Cell Biol.100:843-850(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 242-543
      tissue: Brain.
    9. 9.
      "RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration."
      Lin H. , Zhai J. , Schlaepfer W.W.
      Hum. Mol. Genet.14:3643-3659(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF28
    10. 10.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-473 AND SER-532;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    11. 11.
      "O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry."
      Vosseller K. , Trinidad J.C. , Chalkley R.J. , Specht C.G. , Thalhammer A. , Lynn A.J. , Snedecor J.O. , Guan S. , Medzihradszky K.F. , Maltby D.A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:923-934(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS]
      tissue: Brain.
    12. 12.
      "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
      J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-43;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    13. 13.
      "Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration."
      Balastik M. , Ferraguti F. , Pires-da Silva A. , Lee T.H. , Alvarez-Bolado G. , Lu K.P. , Gruss P.
      Proc. Natl. Acad. Sci. U.S.A.105:12016-12021(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM2;UBIQUITINATION
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